Table 5. Performance comparison of suggested algorithm with existing literatures to classify AD vs. HC.

Method	Modalities	Data	Classifier	ACC	SEN	SPEC
Lama et al. [26]	sMRI	ADNI	ELM	77.88	77.88	68.85
Westman et al. [27]	sMRI	ADNI	OPLS	87	83.30	90.10
Zhang et al. [25]	sMRI	ADNI	SVM	86.2	86	86.3
Proposed method	sMRI+ APoE ε4	ADNI	MK-SVM	94.33	95.40	96.50